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KMID : 0361420080320040469
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Journal of Korean Academy of Rehabilitation Medicine
2008 Volume.32 No. 4 p.469 ~ p.471
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Teicoplanin-induced Elevation of Plasma Creatine Phosphokinase in the Patient with Wound Infection
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Park Geun-Young
Kim Yun-Hee
Park Joo-Hyun
Kim Sae-Hyun
Yang Byung-Woo
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Abstract
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The use of teicoplanin is increasing with increase in the incidence of wound infections caused by methicillin-resistant Staphylococcus aureus. Teicoplanin has longer half-life than vancomycin, so it can be administerd once daily, whereas vancomycin has to be administered 3~4 times daily. Teicoplanin is known to have lesser side effect profiles than vancomycin, such as skin eruptions, ototoxicity and nephrotoxicity. A 27-year old women in vegetative state had a grade 3 pressure sore at coccyx area. We prescribe teicoplanin to manage wound infected by methicillin-resistant Staphylococcus aureus. Plasma creatine phosphokinase (CPK) was elevated abruptly at 9th day of teicoplanin therapy. Five days after discontinuation of teicoplanin, CPK was normalized. We experienced a case of elevation of plasma creatine phosphokinase associated with teicoplanin.
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KEYWORD
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Teicoplanin, Creatine phosphokinase(CPK), Pressure sore
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